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In this webinar, Prof. Eric Reits will discuss how several neurodegenerative disorders, including Alzheimer’s, Parkinson’s and Huntington’s disease, are characterized by the formation of protein aggregates, and that components of the ubiquitin-proteasome system (UPS) co-localize in these aggregates. This has led to speculation that the UPS is impaired in these disorders, with UPS components being irreversibly sequestered and unable to degrade aggregation-prone proteins.

使用各种基于显微镜技术,不同(间接)荧光标记,活性基探针和淬火基质的方法以及活性细胞显微镜实验,并用于证明蛋白质和遍在蛋白是可逆的招募的在聚集体中持续(de)泛素泛素,并且该蛋白质体能够降解这些蛋白质。

Reits_lab_erc_sq-circle.

埃里克博士博士

蜂窝成像教授
研究小组领导和核心设施负责人
AMC-UVA,阿姆斯特丹

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